MCQ of Medical biotechnology: for competative entrance exam

 MCQ of  Medical biotechnology:

 

1.The process of  introduction of  weekend pathogen  into human body is called

a. Attenuation

b. Vaccination

c. immunization

d. none of these

2.The concept of vaccination was first developed by

a. Louis Pasteur

b. Edward jenner

c. Carl Landsteiner

d. Watson and Crick

3. The first vaccine was developed for human use produced using rDNA technology was

a. AIDS Vaccine

b. MMR Vaccine

c. Hepatitis B Vaccine

d. Polio vaccine

4. Synthesis of antibodies takes place by which of the following cells?

a. Bone marrow cells

b. T-cells

c. B-cells

d. Lymph node

5. Who discovered the structure of immunoglobin by treating with beta-mercaptoethanol?

a. Nisonoff

b. Edelman

c. Porter

d. Whittekar

6. Which of the following amino acid found in hinge region?

a.  Alanine , Arginine

b. Asparagine , Cysteine

c. Proline , Cysteine

d. Phenylalanine

7. Which immunoglobin can pass through placenta ?

a. igD

b. igM

c. igE

d. ig G

8. Name the class of immunoglobin which has a pentameric structure?

a. igE

b. igG

c. igA

d. igM

9. Which of these antibody is present in external secretion ?

a. igG

b. igM

c. igA

d.igE

10. The vaccinr consist of the antigen as an important constituent to avoid contamination and increase the immune response other component added during the manufacturing process of a vaccine are tiny amount of an adjuvant ,preservative, and stabilizer . Which of the following is not commonly used adjuvant present in a vaccine ?

a. Formaldehyde

b. Aluminium sulphate

c. Pottassium sulphate

d. Aluminium hydroxide

 

12.Which of the following is the not example of a live attenuated vaccine?

a. Diphtheria vaccine

b. Measles vaccine

c. BCG Vaccine

d. Oral polio vaccine

 

13. Subunit vaccine is all except 

a. A whole purified virus

b. A purified part or pieces of the antigen

c. An exoensive type of vaccine 

d. A Hepatitis -B- vaccine 

14. The first scientifically approved vaccine was 

a. oral polio vaccine 

b. Smallpox vaccine 

c . MMR vaccine 

Tetanus vaccine

15. Antigen such as protein have several different sites that can react with antibodies. These sites are called

a. Paratope

b. Isotope

c. Prototopes

d. Epitope

16. Which of the following statement about monoclonal antibody production is true ?

a. B cell+hybridoma = myeloma 

b. B cell+myeloma = hybridoma

c. B cell+ Spleen cell= Hybridoma

d. Spleen cell+ myeloma = Hybridoma

17. What is the name for the use of rDNA to construct antibodies that use both human source and mouse sources ?

a. rRNA

b. Chimeric monoclonal antibodies

c. vector monoclonal antibodies

d. Transducing monoclonal antibodies

18. Which of the following is not a use of monoclonal antibodies ?

a. Pregnacy test

b. blood and tissue typing 

c. the identification of chromosome normality

d used to prevent organ rejection

19. Which of the following is not a reason why monoclonal antibodies are so useful ? 

a. They are totally uniform

b. they live forever

c. they can be produced in very large quantities at a low cost 

d. they are highly specific

20. What is primary antibody in ELISA?

a. The second antibody used to detect foreign particle

b. Particle produced by the antigen

c. the first antibody used to detect foreign particle 

d. second cell produced by the macrophage

21. Why it is necessary to wash the sample repeatedly ?

a. it is necessary to keep the lab well clean

b. it is important to wash away all bound and unbound antibodies away from the wells

c. it is important to wash away the bound antibodies 

d. Washing the wells just solid lab practice

22. Which of the following contribute to the metastatic spread of cancer cells ? 

a. Cytoskeletal changes and cell adhesion

b. Increased enzyme production 

c. Loss of contact inhibition

d. all of these

23. Which of the following is not the type of cancer ?

a. Carcinoma

b. Sarcomas

c. Leukemia

d. Caspases

24. Name the process by which a malignant cell spread throughout normal cell ?

a. Transformation

b. Metastasis

c. Invasiveness

d.Progression

25. Which of the following is the characterstics of cancer cell ?

a. Ubiquitynation

b. Polymerization

c. Transformation

d Metastasis

26. Which of the following is NOT the example of proto-oncogene ?

a. Rb

b. Src

c. Myc

d. Abl

27.  Which of the following mutation causes Burkitts lymphoma ?

a. Point mutation

b. Chromosomal translocation 

c. Deletion

d. Dulpication

28. Name the gene which directly inhibit cell growth or promote cell death.

a. Gatekeeper genes

b. Caretaker genes

c. Checkpoint

d. Transcription factor

29. If DNA damaged which of the following gene arrest cell cycle ? 

a. Rb

b. p53

c. Hedgehog receptor 

d. p16

30. Name the chemical carcinogen which causes prostate cancer ?

a. Radon

b. Arsenic

c. Cadmium

d. Asbestos

31. Which of the following is an active cell death process?

     a. Apoptosis

     b. Necrosis

     c.Senescence

     d. Lysis

32.Which of the following is an anti apoptotic protein?

    a. Bcl-Xs

    b. Bfl 1

    c. Bim

    d. NOXA

33. Caspases can be activated by______________

a. Cytochrome

b. IAP

c. DNase

d. RNase

34. Which of the following is not a characteristic of apoptotic animal cell?

a. Trasglutaminase forms a net like structure

b. Cell membrane blebbing

c. Mitochondria swollen

d. DNA marginization and fragmentation 

34. The following viruses are associated with human cancers

a. HSV 2

b. EBV

c. HCV

d. Adenoviruses

 

35.  Epstein Bar virus is associated with 

 

a. Kaposi sarcoma

b. Burkitts lymphoma

c. Nasopharyngial carcinoma

d. Adult T cell lymphoma

 

36.  ELISA is

a. Using radiolabelled second antibody

b. Usage of RBCs

c. Using complement-mediated cell lysis

d. Addition of substrate that is converted into a coloured end product

37. The vaccines prepared through recombinant DNA technology are

a. Third generation vaccines

b. First-generation vaccines

c.Second-generation vaccines

d. None

38. The first clinical application of gene therapy over a 4 year old girl was for

a. Adenosine deaminase deficiency

b. Adenosine deficiency

c. Growth deficiency

d. Adenine deficiency

39.  Name the cytokines which released in response to virus infection?

    a) Interferons

    b) Monokines

    c) Lymphokines

    d) Interleukins

 

40. Hepatitis is an example of _______.

(a) Subunit Vaccine

(b) Killer Vaccine

(c) Toxoids Vaccine

(d) Recombinant Vaccine

 

41. Which of the following statements is true about the IgM of humans?

(a) IgM can cross the placenta

(b) IgM can protect the mucosal surface

(c) IgM is produced by high-affinity plasma cells

(d) IgM is primarily restricted in the circulation