Hello friends, In today's article we see the MCQ's of Minerals in biochemistry. So let's see one by one
MCQ's of Minerals in biochemistry:
Mineral MCQ’s in Biochemistry
1.
When ATP forms AMP
(A) Inorganic pyrophosphate is produced
(B) Inorganic phosphorous is produced
(C) Phsophagen is produced
(D) No energy is produced
2.
Standard free energy (∆G°) of
hydrolysis of ATP to ADP + Pi is
(A)
-49.3 KJ/mol
(B)
-4.93 KJ/mol
(C) -30.5 KJ/mol
(D)
-20.9 KJ/mol
3.
Standard free energy (∆G°) of
hydrolysis of ADP to AMP + Pi is
(A)
-43.3 KJ/mol
(B)
-30.5 KJ/mol
(C) -27.6 KJ/mol
(D)
-15.9 KJ/mol
4.
Standard free energy (∆G°) of hydrolysis
of
phosphoenolpyruvate is
(A) -61.9 KJ/mol
(B)
-43.1 KJ/mol
(C)
-14.2 KJ/mol
(D)
-9.2 KJ/mol
5.
Standard free energy (∆G°) of
hydrolysis
of
creatine phosphate is
(A)
--51.4 KJ/mol
(B) -43.1 KJ/mol
(C)
-30.5 KJ/mol
(D)
-15.9 KJ/mol
6.
The oxidation-reduction system
having
the
highest redox potential is
(A) Ubiquinone ox/red
(B) Fe3+ cytochrome a/Fe2+
(C) Fe3+ cytochrome b/Fe2+
(D) NAD+/NADH
7.
If ∆G°= -2.3RT log Keq, the free
energy for the reaction will be
A
+ B
C 10moles 10moles 10moles
(A)
-4.6 RT
(B)
-2.3 RT
(C) +2.3 RT
(D)
+4.6 RT
8.
Redox potential (EO volts)
of NAD+/NADH
is
(A)
-0.67
(B) -0.32
(C)
-0.12
(D)
+0.03
9.
Redox potential (EO volts)
of ubiquinone, ox/red system is
(A)
+0.03
(B)
+0.08
(C) +0.10
(D)
+0.29
10.
Redox potential (EO
volts) of cytochrome C, Fe3+/Fe2+ is
(A)
-0.29
(B)
-0.27
(C)
-0.08
(D) +0.22
11.
The prosthetic group of aerobic
dehydrogenases is
(A) NAD
(B) NADP
(C) FAD
(D) Pantothenic acid
12.
Alcohol dehydrogenase from liver contains
(A) Sodium
(B) Copper
(C) Zinc
(D) Magnesium
13.
A molybdenum containing oxidase is
(A) Cytochrome oxidase
(B) Xanthine oxidase
(C) Glucose oxidase
(D) L-Amino acid oxidase
14.
A copper containing oxidase is
(A) Cytochrome oxidase
(B) Flavin mononucleotide
(C) Flavin adenine dinucleotide
(D) Xanthine oxidase
15.
The mitochondrial superoxide
dismutase
contains
(A) Mg++
(B) Mn++
(C) Co++
(D) Zn++
16.
Cytosolic superoxide dismutase
contains
(A) Cu2+ and Zn2+
(B) Mn2+
(C) Mn2+ and Zn2+
(D) Cu2+ and Fe2+
17.
Cytochrome oxidase contains
(A) Cu2+ and Zn2+
(B) Cu2+ and Fe2+
(C) Cu2+ and Mn2+
(D) Cu2+
Read more MCQ's of Water and Elcetrolyte
18.
Characteristic absorption bands
exhibited
by
ferrocytochrome:
(A) α band
(B) β band
(C) α and β bands
(D) α, β and γ bands
19.
Monooxygenases are found in
(A) Cytosol
(B) Nucleus
(C) Mitochondira
(D) Microsomes
20.
A component of the respiratory chain
in mitochondria is
(A) Coenzyme Q
(B) Coenzyme A
(C) Acetyl coenzyme
(D) Coenzyme containing thiamin
21.
The redox carriers are grouped into
respiratory
chain complex
(A) In the inner mitochondrial membrane
(B) In mitochondiral matrix
(C) On the outer mitochondrial membrane
(D) On the inner surface of outer mitochondrial membrane
22.
The sequence of the redox carrier in
respiratory
chain is
(A) NAD—FMN—Q—cyt b—cyt c1—cyt c—cyt aa3
→ O2
(B) FMN—Q—NAD—cyt b—cyt aa3—cyt c1—
cyt c → O2
(C) NAD—FMN—Q—cyt c1—cyt c—cyt b—cyt aa3
→ O2
(D) NAD—FMN—Q—cyt b—cyt aa3—cyt c—cyt c1
→ O2
23.
The correct sequence of cytochrome
carriers
in respiratory chain is
(A) Cyt b—cyt c—cyt c1—cyt aa3
(B) Cyt aa3— cyt b—cyt c—cyt
c1
(C) Cyt b—cyt c1—cyt c—cyt aa3
(D) Cyt b—cyt aa3—cyt c1—
cyt c
24.
Reducing equivalents from pyruvate
enter
the
mitochondrial respiratory chain at
(A) FMN
(B) NAD
(C) Coenzyme Q
(D) Cyt b
25.
Reducing equivalents from succinate
enter
the
mitochondrial respiratory chain at
(A) NAD
(B) Coenzyme Q
(C) FAD
(D) Cyt c
26.
The respiratory chain complexes
acting as
proton
pump are
(A) I, II and III
(B) I, II and IV
(C) I, III and IV
(D) I and II
27.
If the reducing equivalents enter
from FAD in the respiratory chain, the phosphate.oxygen ration (P:O) is
(A) 2
(B)
1
(C)
3
(D)
4
28.
If the reducing equivalents enter
from NAD in the respiratory chain, the
phsphate/oxygen
(P:O) is
(A)
1
(B)
2
(C) 3
(D)
4
29.
One of the site of phsosphorylation
in mitochondrial respiratory chain is
(A) Between FMN and coenzyme Q
(B) Between coenzyme Q and cyt b
(C) Between cytochrome b and cytochrome c1
(D) Between cytochrome c1 and
cytochrome c
30.
Rotenone inhibits the respiratory
chain at
(A) FMN → coenzyme Q
(B) NAD → FMN
(C) Coenzyme Q → cyt b
(D) Cyt b → Cyt c1
31.
Activity of cytochrome oxidase is
inhibited
by
(A) Sulphite
(B) Sulphate
(C) Arsenite
(D) Cyanide
32.
Transfer of reducing equivalents
from succinate dehydrogenase to coenzyme is specifically inhibited by
(A) Carboxin
(B) Oligomycin
(C) Piericidin A
(D) Rotenone
33.
Chemiosmotic theory for oxidative
phosphorylation
has been proposed by
(A) Chance and Williams
(B) Pauling and Corey
(C) S. Waugh
(D) P. Mitchell
34.
The number of ATP produced in the oxidation
of 1 molecule of NADPH in
oxidative
phosphorylation is
(A) Zero
(B)
2
(C)
3
(D)
4
35.
The coupling of oxidation and
phosphory-
lation
in intact mitochondria:
(A) Puromycin
(B) Oligomycin
(C) Streptomycin
(D) Gentamycin
36.
An uncoupler of oxidative
phosphorylation is
(A) Carboxin
(B) Atractyloside
(C) Amobarbital
(D) Dinitrocresol
37.
The chemical inhibiting oxidative
phosphorylation, Adependent on the transport of adenine nucleotides across the
inner mitochondrial membrane is
(A) Oligomycin
(B) Atractyloside
(C) Dinitrophenol
(D) Pentachlorophenol
38.
Porphyrins are synthesized in
(A) Cytosol
(B) Mitochondria
(C) Cytosol and mitochondria
(D) Rough endoplasmic reticulum
39.
Heme is synthesized from
(A) Succinyl-CoA and glycine
(B) Active acetate and glycine
(C) Active succinate and alanine
(D) Active acetate and alanine
40.
In the biosynthesis of the iron
protoporphyrin, the product of the condensation between succinyl-CoA and
glycine is
(A) α-Amino β-ketoadipic acid
(B) δ-Aminolevulinate
(C) Hydroxymethylbilane
(D) Uroporphyrinogen I
41.
Porphyrin synthesis is inhibited in
(A) Mercury poisoning
(B) Lead poisoning
(C) Manganese poisoning
(D) Barium poisoning
42.
During synthesis of porphyrins,
synthesis
of
δ-amino levulinic acid occurs in
(A) Mitochondria
(B) Cytosol
(C) Both in mitochondria and cytosol
(D) Ribosomes
43.
In the biosynthesis of heme,
condensation between succinyl CoA and glycine requires
(A) NAD+
(B) FAD
(C) NADH + H+
(D) B6-phosphate
44.
In mammalian liver the rate
controlling enzyme in porphyrin biosynthesis is
(A) ALA synthase
(B) ALA hydratase
(C) Uroporphyrinogen I synthase
(D) Uroporphyrinogen III cosynthase
45.
The condensation of 2 molecules of
δ-aminolevulinate
dehydratase contains
(A) ALA synthase
(B) ALA hydratase
(C) Uroporphyrinogen synthase I
(D) Uroporphyrinogen synthase III
46.
The enzyme δ-aminolevulinate dehydratase
contains
(A) Zinc
(B) Manganese
(C) Magnesium
(D) Calcium
47.
A cofactor required for the activity
of the
enzyme
ALA dehydratase is
(A) Cu
(B) Mn
(C) Mg
(D) Fe
48.
The number of molecules of
porphobilinogen required for the formation of a tetrapyrrole i.e., a porphyrin
is
(A)
1
(B)
2
(C)
3
(D) 4
49.
Conversion of the linear
tetrapyrrole hydroxymethylbilane to uroporphyrinogen III
(A) Occurs spontaneously
(B) Catalysed by uroporphyrinogen I synthase
(C) Catalysed by uroporphyrinogen III cosynthase
(D) Catalysed by combined action of uroporphyrinogen
I synthase and uroporphyrinogen III cosynthase
50.
Conversion of uroporphyrinogen III
to coprophyrinogen III is catalysed by the enzyme.:
(A) Uroporphyrinogen decarboxylase
(B) Coproporphyrinogen oxidase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
51.
The synthesis of heme from
protophyrin III is catalysed by the enzyme:
(A) ALA synthase
(B) Ferroreductase
(C) Ferrooxidase
(D) Ferrochelatase
52.
Many xenobiotics
(A) Increase hepatic ALA synthase
(B) Decrease hepatic ALA sythase
(C) Increase hepatic ALA dehydrase
(D) Decrease hepatic ALA dehydrase
53.
Acute intermittent porphyria
(paraoxymal porphyria) is caused due to deficiency of
(A) Uroporphyrinogen I synthase
(B) ALA synthase
(C) Coproporphyrinogen oxidase
(D) Uroporphyrinogen decarboxylase
54.
The major symptom of acute
intermittent
porphyria
includes
(A) Abdominal pain
(B) Photosensitivity
(C) No neuropsychiatric signs
(D) Dermatitis
55.
The characteristic urinary finding
in acute intermittent porphyria is
(A) Increased quantity of uroporphyrin
(B) Increased quantity of coproporphyrin I
(C) Increased quantity of coproporphyrin III
(D) Massive quantities of porphobilinogen
56.
The enzyme involved in congenial
erythropoietic porphyria is
(A) Uroporphyrinogen I synthase
(B) Uroporphyrinogen III cosynthase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
57.
Main symptoms of congenital
erythropoietic porphyria is
(A) Yellowish teeth
(B) Photosensitivity
(C) Abdominal pain
(D) Brownish urine
58.
The probable cause of porphyria
cutaneatarda is deficiency of
(A) Uroporphyrinogen oxidase
(B) Coproporphyrinogen oxidase
(C) Protoporphyrinogen oxidase
(D) Uroporphyrinogen I synthase
59.
The characteristic urinary finding
in porphyria cutanea tarda is
(A) Increased quantity of porphobilinogen
(B) Increased quantity of red cell
protoporphyrin
(C) Increased quantity of uroporphyrin
(D) Increased quantity of δ-ALA
60.
Hereditary coproporphyria is caused
due
to
deficiency of
(A) Protoporphyrinogen oxidase
(B) ALA synthase
(C) ALA dehydratase
(D) Coproporphyrinogen oxidase
61.
The enzyme involved in variegate porphyria
is
(A) Protoporphyrinogen oxidase
(B) Coproporphyrinogen oxidase
(C) Uroporphyrinogen decarboxylase
(D) ALA decarboxylase
62.
Protoporphyria (erythrohepatic) is
characterized by the deficiency of
(A) ALA synthase
(B) ALA hydratase
(C) Protophyrinogen oxidae
(D) Ferrochelatase
63.
The amount of coproporphyrins
excreted
per
day in feces is about
(A)
10-50 µgs
(B)
100-150 µgs
(C)
200-250 µgs
(D) 300-1000 µgs
64.
The immunoglobulins are
differentiated and also named on the basis of
(A) Electrophoretic mobility
(B) Heat stability
(C) Molecular weight
(D) Sedimentaiton coefficient like 7 S, 19 S etc.
65.
The immunoglobulins are classified
on the basis of
(A) Light chains
(B) Heavy chains
(C) Carbohydrate content
(D) Electrophoretic mobility
66.
All immunoglobulins contain
(A)
4 L chains
(B) 4 H chains
(C)
3 L chains
(D) 2 L chains and 2 H chains
67.
An immunoglobulin molecule always
contains
(A)
1 κ and 3 λ type of chains
(B)
2 κ and 2 λ type of chains
(C)
3 κ and 1λ type of chains
(D) 2 κ and 2 λ chains
68
. The number of types of H chains
identified
in
human is
(A)
2
(B)
3
(C)
4
(D) 5
69.
The number of hypervariable region
in L-chain is
(A)
1
(B)
2
(C) 3
(D)
4
70.
The number of hypervariable region
in H
chain
is
(A)
1
(B)
2
(C)
3
(D) 4
71.
Type γ H chain is present in
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
72.
Type α H chain is present in
(A) Ig E
(B) Ig A
(C) Ig M
(D) Ig D
73.
Type µ H chain is present in
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
74.
Type δ H chain is present in
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
75.
Type ε H chain is present in
(A) Ig A
(B) Ig M
(C) Ig D
(D) Ig E
76.
A ‘J’ chain is present in
(A) Ig D
(B) Ig M
(C) Ig G
(D) Ig E
77.
A secretory protein T chain (T
protein) is
present
in
(A) Ig A
(B) Ig M
(C) Ig D
(D) Ig E
78.
A pentamer immunoglobulin is
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig E
79.
The portion of the immunoglobulin molecule
that binds the specific antigen
is
formed by
(A) Variable regions of H and L chains
(B) Constant region of H chain
(C) Constant region of L chain
(D) Hinge region
80.
The class specific function of the
different immunoglobulin molecules is constituted by
(A) Variable region of L chain
(B) Constant region of H chain
(C) Variable region of H chain
(D) Constant region particularly CH2
and CH3 of H chain
81.
Hinge region, the region of Ig
molecule which is flexible and more exposed to
enzymes
is the
(A) Region between first and second constant
regions of H chain (domains CH1 and
CH2)
(B) Region between second and third constant regions
of H chain (CH2 and CH3)
(C) Variable regions of H chain
(D) Variable regions of L chain
82.
The smallest immunoglobulin is
(A) Ig G
(B) Ig E
(C) Ig D
(D) Ig A
83.
The number of sub classes of Ig G is
(A)
2
(B)
3
(C) 4
(D)
8
84.
Most abundant Ig G subclass in the
serum
is
(A) Ig G1
(B) Ig G2
(C) Ig G3
(D) Ig G4
85.
The immunoglobulin which can cross
the
placenta
is
(A)
Ig A
(B) Ig M
(C) Ig G
(D) Ig D
86.
The immunoglobulin possessing lowest
concentration of carbohydrate is
(A)
Ig A
(B) Ig E
(C)
Ig M
(D) Ig G
87.
The normal serum level of Ig G is
(A) 1200 mg%
(B)
500 mg%
(C)
300 mg%
(D)
200 mg%
88.
The half life of Ig G is
(A)
2-8 days
(B)
1-4 days
(C) 19-24 days
(D)
6 days
89.
Most heat labile immunoglobulin is
(A) Ig G
(B) Ig A
(C)
Ig M
(D) Ig D
90.
The immunoglobulin possessing
highest concentration of carbohydrate is
(A)
Ig G
(B) Ig M
(C)
Ig A
(D) Ig D
91.
The normal serum level of Ig D is
(A)
1 mg%
(B)
2 mg%
(C) 3 mg%
(D)
5 mg%
92.
The half life of Ig D is
(A)
1 day
(B) 2-8 days
(C)
10-15 days
(D)
20-24 days
93.
The carbohydrate content of Ig M is
about
(A)
2.8%
(B)
6.4%
(C)
8.0%
(D) 10.2%
94.
The immunoglobulin having highest sedimentation
coefficient is
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
95.
The immunoglobulin having highest molecular
weight is
(A) Ig G
(B) Ig M
(C) Ig E
(D) Ig A
96.
The half life of Ig M is
(A)
2 days
(B)
4 days
(C) 5 days
(D)
8 days
97.
The normal serum level of Ig M is
(A)
50 mg%
(B) 120 mg%
(C)
200 mg%
(D)
300 mg%
98.
The immunoglobulin associated with reginic
antibody is
(A) Ig E
(B) Ig D
(C) Ig M
(D) Ig A
99.
The immunoglobulin having least
concentration in serum is
(A) Ig A
(B) Ig M
(C) Ig D
(D) Ig E
100.
The half life of Ig E protein is
(A) 1-6 days
(B)
2-8 days
(C)
10 days
(D)
20 days
101.
The immunoglobulin which provides highest
antiviral activity is
(A) Ig D
(B) Ig E
(C) Ig A
(D) Ig G
102.
The half life of Ig A is
(A) 6 days
(B)
2-4 days
(C)
5-10 days
(D)
12-20 days
103.
The normal serum level of Ig A is
(A)
100 mg%
(B) 200 mg%
(C)
300 mg%
(D)
400 mg%
104.
Calcium is excreted by
(A) Kidney
(B) Kidney and intestine
(C) Kidney and liver
(D) Kidney and pancreas
105.
A decrease in the ionized fraction of
serum calcium causes
(A) Tetany
(B) Rickets
(C) Osteomalacia
(D) Osteoporosis
106.
A rise in blood calcium may indicate
(A) Paget’s disease
(B) Rickets
(C) Osteomalacia
(D) Hypervitaminosis D
107.
The normal serum level of phosphorus
in
human
adult is
(A)
1-2 mg
(B)
2-3 mg
(C) 3-4.5 mg
(D)
5-7 mg
108.
An increase in carbohydrate metabolism
is accompanied by temporary decrease in serum:
(A)
Calcium
(B) Phosphate
(C)
Iron
(D) Sodium
109.
In rickets of the common low-phosphate
variety, serum phosphate values may go as low as
(A) 1-2 mg/100 ml
(B)
2-3 mg/100 ml
(C)
3-4 mg/100 ml
(D)
4-5 mg/100 ml
110.
The normal serum level of phosphorous in
children varies from
(A)
1-2 mg/100 ml
(B)
2-3 mg/100 ml
(C)
3-4 mg/100 ml
(D) 4-7 mg/100 ml
111.
An inherited or acquired renal tubular
defect in the reabsorption of phosphate (Vit D resistant ricket) is
characterized
with
(A) Normal serum Phosphate
(B) High serum phosphate
(C) A low blood phosphorous with elevated alkaline
Phosphate
(D) A high blood phosphorous with decreased alkaline
phosphatase
112.
The total magnesium content in gms of human
body is about
(A)
5
(B)
10
(C)
15
(D) 21
113.
Iron is a component of
(A) Hemoglobin
(B) Ceruloplasmin
(C) Transferase
(D) Transaminase
114.
Daily requirement of iron for normal adult
male is about
(A)
5 mg
(B) 10 mg
(C)
15 mg
(D)
20 mg
115.
The normal content of protein bound
iron (PBI) in the plasma of males is
(A) 120-140 µg/100 ml
(B)
200-300 µg/100 ml
(C)
120-140 µg/100 ml
(D)
200-300 µg/100 ml
116.
In iron deficiency anemia
(A) The plasma bound iron is low
(B) The plasma bound iron is high
(C) Total iron binding capacity is low
(D) Both the plasma bound iron and total iron binding
capacity are low
117.
The total iron content of the human
body
is
(A)
400-500 mg
(B)
1-2 g
(C)
2-3 g
(D) 4-5 g
118.
In hepatic diseases
(A) Both the bound iron and total iron binding capacity
of the plasma may be low
(B) Both the bound iron and total iron binding
capacity of the plasma may be high
(C) Only bound iron may be high
(D) Only the total iron binding capacity may be high
119.
The recommended daily requirement of iron
for women of 18-55 yrs age is
(A)
5 mg
(B)
8 mg
(C)
10 mg
(D) 15 mg
120.
The percent of total iron in body in hemoglobin
is
(A)
10-20
(B)
20-30
(C)
30-40
(D) 60-70
121.
A hypochromic microcytic anemia with increased
iron stores in the bone marrow may be
(A) Iron responsive
(B) Pyridoxine responsive
(C) Vitamin B12 responsive
(D) Folate responsive
122.
A good source of iron is
(A) Spinach
(B) Milk
(C) Tomato
(D) Potato
123.
The best source of iron is
(A) Organ meats
(B) Milk
(C) Tomato \
(D) Potato
124.
An increased serum iron and decreased iron
binding capacity is found in
(A) Fe deficiency anemia
(B) Sideroblastic anemia
(C) Folate deficiency anemia
(D) Sickle cell anemia
125.
The absorption of iron is increased
2-10 times of normal in
(A) Iron deficiency anemia
(B) Pregnancy
(C) Spherocytosis
(D) Sickle cell anemia
126.
Iron is mainly absorbed from
(A) Stomach and duodenum
(B) Ileum
(C) Caecum
(D) Colon
127.
The iron containing nonporphyrin is
(A) Hemosiderin
(B) Catalase
(C) Cytochrome C
(D) Peroxidase
128.
Molecular iron is
(A) Stored primarily in the spleen
(B) Exreted in the urine as Fe2+
(C) Stored in the body in combination with
ferritin
(D) Absorbed in the ferric form
129.
In hemochromatosis, the liver is
infiltrated
with
(A) Iron
(B) Copper
(C) Molybdenum
(D) Fats
130.
An acquired siderosis-Bantu siderosis
is due to
(A) Foods cooked in iron pots
(B) Diet high in phosphorous
(C) Diet high in calcium
(D) High fat diet
131.
The amount of copper in the human body
is
(A)
50-80 mg
(B) 100-150 mg
(C)
400-500 mg
(D)
500-1000 mg
132.
The amount of copper in muscles is
about
(A)
10 mg
(B)
30 mg
(C) 64 mg
(D)
100 mg
133.
The amount of copper in bones is about
(A)
5 mg
(B)
10 mg
(C)
15 mg
(D) 23 mg
134.
The normal serum of concentration of copper
in mg/100 ml varies between
(A)
0-5
(B)
50-100
(C) 100-200
(D)
200-300
135.
The normal serum concentration of ceruloplasmin
in mg/100 ml varies between
(A)
5-10
(B)
10-20
(C) 25-43
(D)
50-100
136.
Recommended daily dietary requirement of
copper for adults is
(A)
0.5-1 mg
(B)
1.5-3.0 mg
(C) 3.5-4.5 mg
(D)
4.5-5.5 mg
137.
The richest source of copper is
(A) Liver
(B) Milk
(C) Legumes
(D) Green leafy vegetables
138.
The cytosolic superoxide dismutase enzyme
contains
(A) Cu2+
(B) Cu2+ and Zn2+
(C) Zn2+
(D) Mn2+
139.
The deficiency of copper decreases the
activity of the enzyme:
(A) Lysine oxidase
(B) Lysine hydroxylase
(C) Tyrosine oxidase
(D) Proline hydroxylase
140.
Wilson’s disease is a condition of
toxicosis
of
(A) Iron
(B) Copper
(C) Chromium
(D) Molybdenum
141.
In Wilson’s disease
(A) Copper fails to be excreted in the bile
(B) Copper level in plasma is decreased
(C) Ceruloplasmin level is increased
(D) Intestinal absorption of copper is decreased
142.
Menke’s disease is due to an
abnormality
in
the metabolism of
(A)
Iron
(B) Manganese
(C) Magnesium
(D) Copper
143.
Menke’s disease (Kinky or steel hair
disease) is a X-linked disease characterized by
(A)
High levels of plasma copper
(B)
High levels of ceruloplasmin
(C) Low levels of plasma copper and of ceuloplasmin
(D) High level of hepatic copper
144.
The trace element catalyzing
hemoglobin
synthesis
is
(A)
Manganese
(B) Magnesium
(C) Copper
(D) Selenium
145.
The total body content of manganese is
about
(A)
2 mg
(B)
4 mg
(C)
8 mg
(D) 10 mg
146.
In blood the values of manganese in µg
/100 ml varies between
(A)
0-4
(B)
2-4
(C)
3-5
(D) 4-20
147.
The adequate daily dietary requirement
of manganese is
(A)
1-2 mg
(B) 2-5 mg
(C)
5-10 mg
(D)
10-20 mg
148.
Mitochondrial superoxide dismutase contains
(A) Zinc
(B) Copper
(C) Magnesium
(D) Manganese
149.
Mitochondrial pyruvate carboxylase
contains
(A)
Zinc
(B) Zinc
(C) Manganese
(D) Magnesium
150.
The adequate daily dietary requirement
of molybdenum for normal human adult is
(A)
10-20 µg
(B)
25-50 µg
(C)
50-70 µg
(D) 75-200 µg
151.
In human beings molybdenum is mainly absorbed
from
(A) Liver
(B) Kidney
(C) Intestine
(D) Pancreas
152.
In human beings molybdenum is mainly excreted
in
(A) Feces
(B) Sweat
(C) Urine
(D) Tears
153.
Molybdenum is a constituent of
(A) Hydroxylases
(B) Oxidases
(C) Transaminases
(D) Transferases
154.
Safe and adequate daily dietary intake
of
chromium in adults in mg is
(A)
0.01-0.02
(B)
0.02-0.03
(C)
0.03-0.04
(D) 0.05-0.2
155.
Richest source of chromium is
(A) Brewer’s yease
(B) Milk and milk products
(C) Yellow vegetables
(D) Green vegetables
156.
Metallic constituent of “Glucose
tolerance
factor”
is
(A) Sulphur
(B) Cobalt
(C) Chromium
(D) Selenium
157.
Intestinal absorption of chromium is shared
with
(A) Mn
(B) Mg
(C) Ca
(D) Zn
158.
Serum level of chromium in healthy
adult
is
about
(A)
2-5 µg/100 ml
(B) 6-20 µg/100 ml
(C)
30-60 µg/100 ml
(D)
50-100 µg/100 ml
159.
Chromium is potentiator of
(A) Insulin
(B) Glucagon
(C) Thyroxine
(D) Parathromone
160.
Recommended daily dietary allowance of
selenium for adult human in µg is
(A)
20
(B)
40
(C)
50
(D) 70
161.
Total body content of selenium is
about
(A)
1-2 mg
(B)
2-4 mg
(C) 4-10 mg
(D)
50-100 mg
162.
Normal serum level of selenium is
(A)
5 µg /100 ml
(B)
8 µg /100 ml
(C)
10 µg /100 ml
(D) 13 µg /100 ml
163.
Selenium is a constituent of the enzyme:
(A) Glutathione peroxidase
(B) Homogentisate oxidase
(C) Tyrosine hydroxylase
(D) Phenylalanin hydroxylase
164.
A nonspecific intracellular
antioxidant is
(A) Chromium
(B) Magnesium
(C) Selenium
(D) Nickel
165.
Cobalt forms an integral part of the
vitamin:
(A) B1
(B) B6
(C) B12
(D) Folate
166.
Cobalt may act as cofactor for the
enzyme:
(A) Glycl-glycine dipeptidase
(B) Elastase
(C) Polynucleotidases
(D) Phosphatase
167.
Excess intake of cobalt for longer
periods
leads
to
(A) Polycythemia
(B) Megaloblastic anemia
(C) Pernicious anemia
(D) Microcytic anemia
168.
The total sulphur content of the body
is
(A)
25-50 gm
(B)
50-75 gm
(C)
100-125 gm
(D) 150-200 gm
169.
Sulphur is made available to the body
by the amino acids:
(A) Cystine and methionine
(B) Taurine and alanine
(C) Proline and hydroxyproline
(D) Arginine and lysine
170.
Sulphur containing coenzyme is
(A) NAD
(B) FAD
(C) Pyridoxal phosphate
(D) Biotin
171.
Iodine is stored in
(A) Thyroid gland as thyroglobulin
(B) Liver
(C) Intestine
(D) Skin
172.
Iodine is the constituent of
(A) T3 and T4
(B) PTH
(C) Insulin
(D) Adrenaline
173.
Goitrogenic substance present in
cabbage
is
(A) 5-vinyl-2 thio oxalzolidone
(B)
Pyridine-3-carboxylic acid
(C)
3-Hydroxy-4,
5-dihydroxymethyl1-2-methyl pyridine
(D) δ-ALA dehydratase
174.
For an adult male daily requirement of
iodine
is
(A) 25-50 µg
(B)
50-100 µg
(C)
100-150 µg
(D)
200-250 µg
175.
Recommended daily intake of fluoride
for a normal adult is
(A)
1.5-4.0 mg
(B) 0-1 mg
(C)
5-10 mg
(D)
10-20 mg
176.
The percentage of fluoride present in normal
bone is
(A) 0.01-0.03
(B)
0.04-0.08
(C)
0.10-0.12
(D)
0.15-0.2
177.
The percentage of fluoride present in dental
enamel is
(A) 0.01-0.02
(B)
0.05-0.10
(C)
0.15-0.20
(D)
0.20-0.40
178.
Fluorosis occurs due to
(A) Drinking water containing less than 0.2 ppm of
fluorine
(B) Drinking water containing high calcium
(C) Drinking water containing greater than 1.2ppm
of fluroine
(D) Drinking water containing heavy metals
179.
Dental caries occur due to
(A) Drinking water containing less than 0.2 ppm of fluorine
(B)
Drinking water containing greater
than 1.2 ppm of fluorine
(C)
Drinking water containing high
calcium
(D)
Drinking water containing heavy
metals
180.
Total zinc content of human body is
about
(A)
800 mg
(B)
1200 mg
(C) 2000 mg
(D)
3200 mg
181.
Metal required for polymerization of insulin
is
(A) Copper
(B) Chromium
(C) Cobalt
(D) Zinc
182.
Metalloenzyme-retinene for polymerization
of insulin is
(A) Copper
(B) Zinc
(C) Cobalt
(D) Manganese
183.
An important zinc containing enzyme is
(A) Carboxypeptidase A
(B) Isocitrate dehydrogenase
(C) Cholinesterate
(D) Lipoprotein lipase
184.
Acrodermatitis enteropathica is due to
defective absorption of
(A) Manganese
(B) Molybdenum
(C) Iodine
(D) Zinc
185.
Hypogonadism develops due to
deficiency
of
(A) Sulphur
(B) Cobalt
(C) Zinc
(D) Manganese
186.
Psychotic symptoms and parkinsonism like
symptoms develop due to inhalation poisoning of
(A) Manganese
(B) Phosphorous
(C) Magnesium
(D) Zinc
187.
One gram of carbohydrate on complete oxidation
in the body yields about
(A)
1 Kcal
(B) 4 Kcal
(C)
6 Kcal
(D)
9 Kcal
188.
One gram of fat on complete oxidation in
the body yields about
(A)
4 Kcal
(B)
6 Kcal
(C) 9 Kcal
(D)
12 Kcal
189.
One gram of protein on complete oxidation
in the body yields about
(A)
2 Kcal
(B) 4 Kcal
(C)
8 Kcal
(D)
12 Kcal
190.
R.Q. of mixed diet is about
(A)
0.70
(B)
0.80
(C) 0.85
(D)
1.0
191.
R.Q. of proteins is about
(A)
0.70
(B)
0.75
(C) 0.80
(D)
0.85
192.
R.Q. of carbohydrates is about
(A)
0.75
(B)
0.80
(C)
0.85
(D) 1.0
193.
R.Q. of fats is about
(A) 0.75
(B)
0.80
(C)
0.85
(D)
1.0
194.
Proteins have the SDA:
(A)
5%
(B)
10%
(C)
20%
(D) 30%
195.
Humans most easily tolerate a lack of
the
nutrient:
(A) Protein
(B)
Lipid
(C) Iodine
(D) Carbohydrate
196.
The basal metabolic rate (B.M.R.) is measurement
of
(A) Energy expenditure during sleep
(B) Energy expenditure after 100 m walk
(C) Energy expenditure after a meal
(D) Energy expenditure under certain basal (Standard)
conditions
197.
B.M.R. is raised in
(A) Polycythemia
(B) Starvation
(C) Lipid nephrosis
(D) Hypothyroidism
198.
B.M.R. is lowered in
(A) Hypothyroidism
(B) Leukemia
(C) Cardiac failure
(D) Hyperthyroidism
199.
B.M.R. is subnormal in
(A) Addison’s disease
(B)
Adrenal tumour
(C)
Cushing’s syndrome
(D)
Fever
200.
A healthy 70 kg man eats a well
balanced diet containing adequate calories and 62.5 g of high quality protein
per day. Measured in grams of nitrogen, his daily nitrogen balance would be
(A)
+10 g
(B)
+6.25 g
(C) 0 g
(D)
-6.25 g
201.
The percentage of nitrogen retained in
the body after absorption of diet represents
(A)
Digestibility coefficient of proteins
(B) Biological value of proteins
(C)
Protein efficiency ratio
(D)
Net protein utilisation
202.
In a person increase in weight in gms
per gm of protein consumption represents
(A) Protein efficiency ratio
(B)
Digestibility value of proteins
(C) Biological value of proteins
(D)
Net protein utilisation
203.
The percentage of food nitrogen that
is retained in the body represents
(A)
Digestibility coefficient
(B)
Biological value of proteins
(C)
Protein efficiency ratio
(D) Net protein utilisation
204.
The chemical score of different
proteins is calculated in terms of
(A) Egg proteins
(B) Milk proteins
(C)
Fish proteins
(D) Wheat proteins
205.
Biological value of egg protein is
(A) 94
(B)
60
(C)
51
(D)
40
206.
Biological value of protein of cow’s
milk is
(A)
95
(B) 60
(C)
71
(D)
67
207.
Biological value of soyabean protein
is
(A)
86
(B)
71
(C) 64
(D)
54
208.
Plasma bicarbonate is decreased in
(A) Respiratory alkalosis
(B) Respiratory acidosis
(C) Metabolic alkalosis
(D) Metabolic acidosis
209.
Plasma bicarbonate is increased in
(A) Respiratory alkalosis
(B) Metabolic alkalosis
(C) Respiratory acidosis
(D) Metabolic acidosis
210.
Total CO2 is increased in
(A) Respiratory acidosis
(B) Metabolic alkalosis
(C) Both respiratory acidosis and metabolic alkalosis
(D) Respiratory alkalosis
211.
Respiratory acidosis is caused by
(A) Increase in carbonic acid relative to bicarbonate
(B) Decrease in bicarbonate fraction
(C) Increase in bicarbonate fraction
(D) Decrease in the carbonic acid
fraction
212.
Respiratory alkalosis is caused by
(A) An increase in carbonic acid fraction
(B) A decrease in bicarbonic fraction
(C) A decrease in the carbonic acid fraction
(D) An increase in bicarbonate fraction
213.
Meningitis and encephalitis cause
(A) Metabolic alkalosis
(B) Respiratory alkalosis
(C) Metabolic acidosis
(D) Respiratory acidosis
214.
Metabolic acidosis is caused in
(A) Uncontrolled diabetes with ketosis
(B) Pneumonia
(C) Intestinal Obstruction
(D) Hepatic coma
215.
Metabolic acidosis is caused in
(A) Pneumonia
(B) Prolonged starvation
(C) Intestinal obstruction
(D) Bulbar polio
216.
Respiratory acidosis occurs in
(A) Any disease which impairs respiration like emphysema
(B) Renal disease
(C) Poisoning by an acid
(D) Pyloric stenosis
217.
Metabolic alkalosis occurs
(A) As consequence of high intestinal obstruction
(B) In central nervous system disease
(C) In diarrhoea
(D) In colitis
218.
Respiratory alkalosis occurs in
(A) Hysterical hyperventilation
(B) Depression of respiratory centre
(C) Renal diseases
(D) Loss of intestinal fluids
219.
Morphine poisoning causes
(A) Metabolic acidosis
(B) Respiratory acidosis
(C) Metabolic alkalosis
(D) Respiratory alkalosis
220.
Salicylate poisoning in early stages
causes
(A) Metabolic acidosis
(B) Respiratory acidosis
(C) Metabolic alkalosis
(D) Respiratory alkalosis
221.
The compound having the lowest redox potential
amongst the following is
(A) Hydrogen
(B) NAD
(C) Cytochrome b
(D) Cytochrome a
222.
All the oxidases contain a metal which
is
(A) Copper
(B) FAD
(C) Manganese
(D) None of these
223.
Isocitrate dehydrogenases is
(A) Aerobic dehydrogenase
(B) Anaerobic dehydrogenase
(C) Hydroperoxidase
(D) Oxygenase
224.
Iron-pophyrin is present as prosthetic
group in
(A) Cytochromes
(B) Catalases
(C) Peroxidase
(D) None of these
225.
Microsomal hydroxylase system contains
a
(A) Di-oxygenase
(B) Mono-oxygenase
(C) Both (A) and (B)
(D) None of thse
226.
Superoxide radicals can be detoxified
by
(A) Cytochrome c
(B) Cytochrome b
(C) Cytochrome a
(D) None of these
227.
A copper containing cytochrome is
(A) Cytochrome a
(B) Cytochrome P-450
(C) Cytochrome a3
(D) None of these
228.
Rate of tissue respiration is raised
when the intracellular concentration of
(A) ADP increases
(B) ATP increases
(C) ADP decreases
(D) None of these
229.
Which of the following component of respiratory
chain is not attached to the
inner
mitochondrial membrane?
(A) Coenzyme Q
(B) Cytochrome c
(C) Both (A) and
(B)
(D)
None of these
230.
In some reactions, energy is captured
in the form of
(A) GTP
(B) UTP
(C) CTP
(D) None of these
231.
Substrate-linked phosphorylation
occurs in
(A) Glycolytic pathway
(B) Citric acid cycle
(C) Both (A) and (B)
(D) None of these
232.
Hydrogen peroxide may be detoxified in
the absence of an oxygen acceptor by
(A) Peroxidase
(B) Catalase
(C) Both (A) and (B)
(D) None of these
233.
Superoxide radicals can be detoxified
by
(A) Cytochrome c
(B) Superoxide dismutase
(C) Both (A) and (B)
(D) None of these
234.
The porphyrin present in haem is
(A) Uroporphyrin
(B) Protoporphyrin I
(C) Coproporphyrin
(D) Protoporphyrin II
235.
An amino acid required for porphyrin
synthesis
is
(A) Proline
(B) Glycine
(C) Serine
(D) Histidine
236.
Which of the following coenzyme is required
for porphyrin synthesis?
(A) Coenzyme A
(B) Pyridoxal phosphate
(C) Both (A) and (B)
(D) None of these
237.
The
regulatory enzyme for
haem
synthesis
is
(A) ALA synthetase
(B) haem synthetase
(C) Both (A) and (B)
(D) None of these
238.
Regulation of haem synthesis occurs by
(A) Covalent modification
(B) Repression - derepression
(C) Induction
(D) Allosteric regulation
239.
Sigmoidal oxygen dissociation curve is
a
property
of
(A) Haemoglobin
(B) Carboxyhaemoglobin
(C) Myoglobin
(D) Methaemoglobin
240.
Cyanmethaemoglobin can be formed
from
(A) Oxy Hb
(B) Met Hb
(C) Carboxy Hb
(D) All of these
241.
In thalassemia, an amino acid is
substituted
in
(A) Alpha chain
(B) Beta chain
(C) Alpha and beta chains
(D) Any chain
242.
Haem synthetase is congenitally
deficient
in
(A) Congenital erythropoietic porphyria
(B) Protoporphyria
(C) Hereditary coproporphyria
(D) Variegate porphyria
243.
During breakdown of haem, the methenyl
bridge between the following two pyrrole rings is broken:
(A) I and II
(B) II and III
(C) III and IV
(D) IV and I
244.
Pre- hepatic jaundice occurs because
of
(A) Increased haemolysis
(B) Liver damage
(C) Biliary obstruction
(D) None of these
245.
kernicterus can occur in
(A) Haemolytic jaundice
(B) Hepatic jaundice
(C) Obstructive jaundice
(D) All of these
246.
Bile pigments are not present in urine
in
(A) Haemolytic jaundice
(B) Hepatic jaundice
(C) Obstructive jaundice
(D) Rotor’s syndrome
247.
Serum alkaline phosphatase is greatly
increased
in
(A) Haemolytic jaundice
(B) Hepatic jaundice
(C) Obstructive jaundice
(D) None of these
248.
The active transport system for
hepatic uptake of bilirubin is congenitally
defective
in
(A) Gilbert’s disease
(B) Crigler-Najjar syndrome
(C) Rotor’s syndrome
(D) Dubin-Johnson syndrome
249.
Bilirubin UDP-glucuronyl transferase
is
absent
from liver in
(A) Crigler-Najjar syndrome, type I
(B) Gilbert’s disease
(C) Crigler-Najjar syndrome, type II
(D) Rotor’s syndrome
250.
Unconjugated bilirubin in serum is soluble
in
(A) Water
(B) Alkalis
(C) Acids
(D) Methanal
251.
Excretion of conjugated bilirubin from
liver cells into biliary canaliculi is defective in
(A) Gilbert’s disease
(B) Crigler-Najjar syndrome
(C) Lucey-Driscoll syndrome
(D) Rotor’s syndrome
252.
Breakdown of 1gm haemoglobin pro-
duces
(A)
20 mg of bilirubin
(B) 35 mg of bilirubin
(C)
50 mg of bilirubin
(D)
70 mg of bilirubin
253.
Variable regions are present in
(A) Immunoglobulins
(B) α-Chains of T cell receptors
(C) β-Chains of T cell receptors
(D) All of these
254.
The total amount of calcium in an
average adult man is about
(A)
100 gm
(B)
500 gm
(C) 1 kg
(D)
10 kg
255.
The following proportion of the total
body calcium is present in bones and teeth:
(A)
75%
(B)
90%
(C)
95%
(D) 99%
256.
The normal range of plasma calcium is
(A)
3-5 mg/dl
(B)
5-10 mg/dl
(C) 9-11 mg/dl
(D)
11-15 mg/dl
257.
Which of the normal range of ionized calcium
in plasma is
(A)
2-4 mg/dl
(B)
2-4 mEq/L
(C) 4-5 mg/dl
(D)
4-5 mEq/L
258.
Tetany can occur in
(A) Hypocalcaemia
(B) Hypercalcaemia
(C) Alkalosis
(D) Hypocalcaemia and alkalosis
259.
Intestinal absorption of calcium
occurs by
(A) Active takeup
(B) Simple diffusion
(C) Facilitated diffusion
(D) Endocytosis
260.
Intestinal absorption of calcium is hampered
by
(A) Phosphate
(B) Phytate
(C) Proteins
(D) Lactose
261.
Calcitriol facilitates calcium
absorption by increasing the synthesis of the following in intestinal mucosa:
(A) Calcium Binding Protein
(B) Alkaline Phosphatase
(C) Calcium-dependent ATPase
(D) All of these
262.
A high plasma calcium level decreases intestinal
absorption of calcium by
(A) Stimulating the secretion of parathormone
(B) Inhibiting the secretion of parathormone
(C) Decreasing the synthesis of cholecalciferol
(D) Inhibiting the secretion of thyrocalcitonin
263.
The daily calcium requirement of an
adult
man
is about
(A)
400 mg
(B)
600 mg
(C) 800 mg
(D)
1,000 mg
264.
The daily calcium requirement in pregnancy
and lactation is about
(A)
600 mg
(B)
800 mg
(C) 1,200 mg
(D)
1,500 mg
265.
Hypercalcaemia can occur in all the
following except
(A) Hyperparathyroidism
(B) Hypervitaminosis D
(C) Milk alkali syndrome
(D) Nephrotic syndrome
266.
Hypocalcaemia can occur in all the
following except
(A)
Rickets
(B)
Osteomalacia
(C) Hyperparathyroidism
(D) Intestinal malabsorption
267.
The major calcium salt in bones is
(A)
Calcium carbonate
(B)
Calcium chloride
(C)
Calcium hydroxide
(D) Calcium phosphate
268.
The correct statement about serum inorganic
phosphorous concentration is
(A)
It is higher in men than in women
(B)
It is higher in women than in men
(C)
It is higher in adults than in
children
(D) It is higher in children than in adults
269.
The product of serum calcium concentration
(mg/dl) and serum inorganic phosphorous concentration (mg/dl) in adults is
about
(A) 30
(B)
40
(C)
50
(D)
60
270.
The product of serum calcium concentration
(mg/dl) and serum inorganic phosphorous concentration (mg/dl) in children is
about
(A)
30
(B)
40
(C) 50
(D)
60
271.
The product of serum calcium
concentration
(mg/dl)
and serum inorganic phosphorous
concentration
(mg/dl) is decreased in
(A) Rickets
(B) Hypoparathyroidism
(C) Hyperparathyroidism
(D) Renal failure
272.
Serum inorganic phosphorous rises in
all
the
following conditions except
(A) Hypoparathyroidism
(B) Hypervitaminosis D
(C) Chronic renal failure
(D) After a carbohydrate-rich meal
273.
Serum inorganic phosphorous decreases
in
all the following conditions except
(A) Hyperparathyroidism
(B) Intestinal malabsorption
(C) Osteomalacia
(D) Chronic renal failure
274.
Serum magnesium level ranges between
(A) 2-3 mg/dl
(B)
3-5 mg/dl
(C)
6-8 mg/dl
(D)
9-11 mg/dl
275.
Magnesium ions are required in the reactions
involving
(A) NAD
(B) FAD
(C) ATP
(D) CoA
276.
Normal range of serum sodium is
(A)
30-70 mEq/L
(B)
70-110 mEq/L
(C)
117-135 mEq/L
(D) 136-145 mEq/L
277.
Sodium is involved in the active
uptake of
(A) D-Glucose
(B) D-Galactose
(C) L-Amino acids
(D) All of these
278.
Aldosterone increases reabsorption of sodium
in
(A) Proximal convoluted tubules
(B) Ascending limb of loop of Henle
(C) Descending limb of loop of Henle
(D) Distal convoluted tubules
279.
Restriction of sodium intake is
commonly
advised
in
(A) Addison’s disease
(B) Diarrhoea
(C) Hypertension
(D) None of these
280.
Serum sodium level rises in all of the
following except
(A) Renal failure
(B) Prolonged steroid therapy
(C) Aldosteronism
(D) Dehydration
281.
Hyponatraemia occurs in the following
condition:
(A) Addison’s disease
(B) Chronic renal failure
(C) Severe diarrhoea
(D) All of these
282.
Serum potassium level decreases in
(A) Familial periodic paralysis
(B) Addison’s disease
(C) Renal failure
(D) All of these
283.
Concentration of the following is
higher in intracellular fluid than in extracellular fluid:
(A) Sodium
(B) Potassium
(C) Chloride
(D) Bicarbonate
284.
Normal range of serum potassium is
(A)
2.1-3.4 mEq/L
(B) 3.5-5.3 mEq/L
(C)
5.4-7.4 mEq/L
(D)
7.5-9.5 mEq/L
285.
Normal range of serum chloride is
(A)
24-27 mEq/L
(B)
70-80 mEq/L
(C) 100-106 mEq/L
(D)
120-140 mEq/L
286.
An extracellular fluid having a higher
concentration of chloride than serum is
(A) Bile
(B) Sweat
(C) CSF
(D) Pancreatic juice
287
Total amount of iron in an adult man
is
about
(A)
1-2 gm
(B)
2-3 gm
(C) 3-4 gm
(D)
6-7 gm
288.
Haemoglobin contains about
(A)
30% of the total body iron
(B)
50% of the total body iron
(C) 75% of the total body iron
(D)
90% of the total body iron
289.
About 5% of the total body, iron is
present
in
(A) Transferrin
(B) Myoglobin
(C) Cytochromes
(D) Haemosiderin
290.
Each haemoglobin molecule contains
(A) One iron atom
(B) Two iron atoms
(C) Four iron atoms
(D) Six iron atoms
291.
Each myoglobin molecule contains
(A) One iron atom
(B) Two iron atoms
(C) Four iron atoms
(D) Six iron atoms
292.
Apoferritin molecule is made up of
(A) Four subunits
(B) Eight subunits
(C) Ten subunits
(D) Twenty-four subunits
293.
Ferritin is present in
(A) Intestinal mucosa
(B) Liver
(C) Spleen
(D) All of these
294.
Iron is stored in the form of
(A) Ferritin and transferrin
(B) Transferrin and haemosiderin
(C) Haemoglobin and myoglobin
(D) Ferritin and haemosiderin
295.
Iron is transported in blood in the
form
of
(A) Ferritin
(B) Haemosiderin
(C) Transferrin
(D) Haemoglobin
296.
Molecular weight of transferrin is
about
(A)
40,000
(B)
60,000
(C) 80,000
(D)
1,00,000
297.
Normal plasma iron level is
(A)
50100 µg/dl
(B)
100150 µg/dl
(C) 50175 µg/dl
(D)
250400 µg/dl
298.
Iron is present in all the following except
(A) Peroxidase
(B) Xanthine oxidase
(C) Aconitase
(D) Fumarase
299.
Total daily iron loss of an adult man
is about
(A)
0.1 mg
(B) 1 mg
(C)
5 mg
(D)
10 mg
300.
Iron absorption is hampered by
(A) Ascorbic acid
(B) Succinic acid
(C) Phytic acid
(D) Amino acid
301.
Iron absorption is hampered by
(A) In achlorhydria
(B) When ferritin content of intestinal mucosa is
low
(C) When saturation of plasma transferring is low
(D) When erythropoietic activity is increased
302.
Daily iron requirement of an adult man
is
about
(A)
1 mg
(B)
5 mg
(C) 10 mg
(D)
18 mg
303.
Daily iron requirement of a woman of reproductive
age is about
(A)
1 mg
(B)
2 mg
(C)
10 mg
(D) 20 mg
304.
All the following are good sources of
iron except
(A) Milk
(B) Meat
(C)
Liver
(D) Kidney
305.
Relatively more iron is absorbed from
(A)
Green leafy vegetables
(B) Fruits
(C) Whole grain cereals
(D) Organ meats
306.
Iron absorption from a mixed diet is
about
(A)
1-5 %
(B) 5-10 %
(C)
20-25 %
(D)
25-50 %
307.
Iron deficiency causes
(A) Normocytic anaemia
(B) Microcytic anaemia
(C) Megaloblastic anaemia
(D) Pernicious anaemia
308.
Prolonged and severe iron deficiency
can cause astrophy of epithelium of
(A) Oral cavity
(B) Oesophagus
(C) Stomach
(D) All of these
309.
All of the following statements about bronzed
diabetes are true except
(A) It is caused by excessive intake of copper
(B) Skin becomes pigmented
(C) There is damage to β cells of Islets of
Langerhans
(D) Liver is damaged
310.
The total amount of iodine in the body
of an average adult is
(A)
10-15 mg
(B)
20-25 mg
(C) 45-50 mg
(D)
75-100 mg
311.
Iodine content of thyroid gland in an adult
is about
(A)
1-3 mg
(B)
4-8 mg
(C) 10-15 mg
(D)
25-30 mg
312.
Daily iodine requirement of an adult
is about
(A)
50 µg
(B)
100 µg
(C) 150 µg
(D)
1 mg
313.
Consumption of iodised salt is recommended
in
(A) Patients with hyperthyroidism
(B) Patients with hypothyroidism
(C) Pregnant women
(D) Goitre belt areas
314.
All the following statements about endemic
goiter are true except
(A) It occurs in areas where soil and water have low iodine content
(B) It leads to enlargement of thyroid gland
(C) It results ultimately in hyperthyroidism
(D) It can be prevented by consumption of iodised
salt
315.
The total amount of copper in the body
of
an average adult is
(A)
1 gm
(B)
500 mg
(C) 100 mg
(D)
10 mg
316.
The normal range of plasma copper is
(A)
25-50 µg/dl
(B)
50-100 µg/dl
(C) 100-200 µg/dl
(D)
200-400 µg/dl
317.
Copper deficiency can cause
(A) Polycythaemia
(B) Leukocytopenia
(C) Thrombocytopenia
(D) Microcytic anaemia
318.
Daily requirement of copper in adults
is about
(A)
0.5 mg
(B)
1 mg
(C) 2.5 mg
(D)
5 mg
319.
All the following statements about ceruloplasmin
are correct except
(A) It is a copper-containing protein
(B) It possesses oxidase activity
(C) It is synthesised in intestinal mucosa
(D) Its plasma level is decreased inWilson’s disease
320.
All the following statements about
Wilson’s
disease are correct except
(A) It is a genetic disease
(B) The defect involves copper-dependent P-type ATPase
(C) Copper is deposited in liver, basal ganglia
and around cornea
(D) Plasma copper level is increased in it
321.
Which of the following statements
about
Menke’s
disease are true.
(A) It is an inherited disorder of copper
metabolism
(B) It occurs only in males
(C) Plasma copper is increased in it
(D) Hair becomes steely and kinky in it
322.
The total amount of zinc in an average
adult
is
(A)
0.25-0.5 gm
(B)
0.5-1.0 gm
(C) 1.5-2.0 gm
(D)
2.5-5.0 gm
323.
Plasma zinc level is
(A)
10-50 µg/dl
(B) 50-150 µg/dl
(C)
150-250 µg/dl
(D)
250-500 µg/dl
324.
Zinc is a cofactor for
(A) Acid phosphatase
(B) Alkaline phosphatase
(C) Amylase
(D) Lipase
325.
Zinc is involved in storage and
release of
(A) Histamine
(B) Acetylcholine
(C) Epinephrine
(D) Insulin
326.
Intestinal absorption of zinc is
retarded by
(A) Calcium
(B) Cadmium
(C) Phytate
(D) All of these
327.
The daily zinc requirement of an
average adult is
(A)
5 mg
(B)
10 mg
(C) 15 mg
(D)
25 mg
328.
Zinc deficiency occurs commonly in
(A) Acrodermatitis enteropathica
(B) Wilson’s disease
(C) Xeroderma pigmentosum
(D) Menke’s disease
329.
Hypogonadism can occur in deficiency
of
(A) Copper
(B) Chromium
(C) Zinc
(D) Manganese
330.
Healing of wounds may be impaired in deficiency
of
(A) Selenium
(B) Copper
(C) Zinc
(D) Cobalt
331.
Hypochromic microcytic anaemia can occur
in
(A) Zinc
(B) Copper
(C) Manganese
(D) None of these
332.
The daily requirement for manganese in
adults is about
(A)
1-2 mg
(B) 2-5 mg
(C)
2-5 µg
(D)
5-20 µg
333.
Molybdenum is a cofactor for
(A) Xanthine oxidase
(B) Aldehyde oxidase
(C) Sulphite oxidase
(D) All of these
334.
A trace element having antioxidant
function
is
(A) Selenium
(B) Tocopherol
(C) Chromium
(D) Molybdenum
335.
Selenium is a constituent of
(A) Glutathione reductase
(B) Glutathione peroxidase
(C) Catalase
(D) Superoxide dismutase
336.
Selenium decreases the requirement of
(A) Copper
(B) Zinc
(C) Vitamin D
(D) Vitamin E
337.
Upper safe limit of fluorine in water
is
(A)
0.4 ppm
(B)
0.8 ppm
(C) 1.2 ppm
(D)
2 ppm
338.
The daily fluoride intake should not exceed
(A)
0.5 mg
(B)
1 mg
(C)
2 mg
(D) 3 mg
339.
In adults, water constitutes about
(A)
50% of body weight
(B)
55% of body weight
(C) 60% of body weight
(D)
75% of body weight
340.
1 kcal is roughly equal to
(A)
4.2 J
(B)
42 J
(C) 4.2 KJ
(D)
42 KJ
341.
Calorific value of proteins as
determined
in
a bomb calorimeter is
(A)
4 kcal/gm
(B)
4.8 kcal/gm
(C) 5.4 kcal/gm
(D)
5.8 kcal/gm
342.
Calorific value of proteins in a
living person is less than that in a bomb calorimeter because
(A)
Digestion and absorption of proteins
is less than 100%
(B)
Respiratory quotient of proteins is
less than 1
(C)
Specific dynamic action of proteins
is high
(D) Proteins are not completely oxidized in living persons
343.
Calorific value of alcohol is
(A)
4 kcal/gm
(B)
5.4 kcal/gm
(C) 7 kcal/gm
(D)
9 kcal/gm
344.
Energy expenditure of a person can be measured
by
(A)
Bomb calorimetry
(B)
Direct calorimetry
(C)
Indirect calorimetry
(D) Direct or indirect calorimetry
345.
Respiratory quotient of carbohydrates
is
about
(A)
0.5
(B)
0.7
(C)
0.8
(D) 1.0
346.
Respiratory quotient of fats is about
(A)
0.5
(B) 0.7
(C)
0.8
(D)
1.0
347.
Respiratory quotient of proteins is
about
(A)
0.5
(B)
0.7
(C) 0.8
(D)
1.0
348.
Respiratory quotient of an average
mixed diet is about
(A)
0.65
(B)
0.7
(C)
0.75
(D) 0.85
349.
At a respiratory quotient of 0.85,
every litre of oxygen consumed represents an energy expenditure of
(A)
5.825 kcal
(B) 4.825 kcal
(C)
3.825 kcal
(D)
2.825 kcal
350.
BMR of healthy adult men is about
(A)
30 kcal/hour/square metre
(B)
35 kcal/hour/square metre
(C) 40 kcal/hour/square metre
(D)
45 kcal/hour/square metre
351.
BMR of healthy adult women is about
(A)
32 kcal/hour/square metre
(B) 36 kcal/hour/square metre
(C)
40 kcal/hour/square metre
(D)
44 kcal/hour/square metre
352.
BMR is higher in
(A) Adults than in children
(B) Men than in women
(C) Vegetarians than in non-vegetarians
(D) Warmer climate than in colder climate
353.
BMR is decreased in
(A) Pregnancy
(B) Starvation
(C) Anaemia
(D) Fever
354.
BMR is increased in
(A) Starvation
(B) Hypothyroidism
(C) Addison’s disease
(D) Pregnancy
355.
BMR is decreased in all of the
following except
(A) Fever
(B) Addison’s disease
(C) Starvation
(D) Hypothyroidism
356.
BMR is increased in all of the
following except
(A) Hyperthyroidism
(B) Anaemia
(C) Addison’s disease
(D) Pregnancy
357.
Specific dynamic action of
carbohydrates is about
(A) 5%
(B)
13%
(C)
20%
(D)
30%
358.
Specific dynamic action of proteins is
about
(A)
5%
(B)
13%
(C)
20%
(D) 30%
359.
All following are essential trace
elements except
(A) Iron
(B) Iodine
(C) Zinc
(D) Cadmium
360.
Maximum quantity of sodium is excreted
through
(A) Urine
(B) Faeces
(C) Sweat
(D) None of these
361.
All followings are rich sources of magnesium,
except
(A) Milk
(B) Eggs
(C) Meat
(D) Cabbage
362.
All followings are poor sources of
iron except
(A) Milk
(B) Potatoes
(C) Wheat flour
(D) Liver
363.
The Iron deficient children,
absorption of Iron from GIT is
(A) Unaltered
(B) Double than in normal child
(C) Manifold than in normal child
(D) Lesser than in normal child
364.
Main source of fluoride for human
beings
is
(A) Milk
(B) Water
(C) Vegetables
(D) Eggs
365.
Quantity of copper present in the body
of
an adult is
(A)
0-50 mg
(B)
50-100 mg
(C) 100-150 mg
(D)
150-250 mg
366.
A level of 310-340 mg per 1000 ml of blood
is normal for the
(A) Copper
(B) Iron
(C) Potassium
(D) Sodium
367.
Daily requirement of phosphorous for
an infant is
(A) 240-400 mg
(B)
1.2 gms
(C)
800 mg
(D)
800-1200 mg
368.
Maximum quantity of Zinc is present in
the body in
(A) Prostate
(B) Choroid
(C) Skin
(D) Bones
369.
Average concentration of chloride ions
in cerebrospinal fluid per 100 ml is
(A)
40 mg
(B) 440 mg
(C)
160 mg
(D)
365 mg
370.
Total iron content of the normal adult
is
(A)
1-2 gm
(B)
3-4 gm
(C) 4-5 gm
(D)
7-10 gm
371.
Absorption of phosphorous from diet is
favoured by
(A) Moderate amount of fat
(B) Acidic environment
(C) High calcium content
(D) High phytic acid
372.
Daily intake of potassium for a normal
person should be
(A)
1 gm
(B)
2 gm
(C)
3 gm
(D) 4 gm
373.
Absorption of calcium decreases if
there is high concentration in the diet of
(A) Copper
(B) Sodium
(C) Magnesium
(D) Cadmium
374.
Of the following highest concentration
of
calcium
is seen in
(A) Blood
(B) CSF
(C) Muscle
(D) Nerve
375.
Cobalt is essential component of
(A) Vitamin B1
(B) Vitamin B6
(C) Vitamin B12
(D) All of these
376.
Iodine is required in human body for
(A) Formation of thyroxine
(B) Formation of Glutathione
(C) Formation of potassium iodide
(D) Adrenalin
377.
A hypochromic necrocytic anaemia with increase
Fe stores in the bone marrow may be
(A) Folic acid responsive
(B) Vitamin B12 responsive
(C) Pyridoxine responsive
(D) Vitamin C responsive
378.
A deficiency of copper effects the
formation of normal collagen by reducing the activity of which of the following
enzyme?
(A) Prolyl hydroxylase
(B) Lysyl oxidase
(C) Lysyl hydroxylase
(D) Glucosyl transferase
379.
Molecular iron (Fe) is
(A) Stored primarily in spleen
(B) Absorbed in the intestine
(C) Absorbed in the ferric, Fe+++ form
(D) Stored in the body in combination with
ferritin
380.
All the following statements regarding
calcium are correct except
(A) It diffuses as a divalent cation
(B) It freely diffuses across the endoplasmic
reticulum of muscle cells
(C) It can exist in the blood as ionic form and
also protein bound
(D) It is found in high concentration in bones
381.
Iron is absorbed from
(A) Stomach
(B) Duodenum and jejunum
(C) Ileum
(D) Noen of the above
382.
The normal route of calcium excretion
is
(A) Kidney
(B) Kidney and Liver
(C) Kidney and Intestine
(D) Kidney, Intestine and Pancreas
383.
Hypocalcaemia affects
(A) Skeletal muslces
(B) Smooth muscles
(C) Cardiac muscles
(D) Skeletal muscles + smooth muscles + cardiac muscles
384.
Transferrin is a type of
(A) Albumin
(B) α-globulin
(C) β1 globulin
(D) γ-globulin
385.
In case of wilson’s disease, the
features include all of the following except
(A) Progressive hepatic cirrhosis
(B) Keyser Fleisher ring
(C) Aminoaciduria
(D) Urinary excretion of Cu is decreased
386.
In Vitamin D poisoning
(hyper-vitaminosis)
(A) Both serum and urinary “Ca”
(B) The serum Ca is low and urinary calcium high
(C) The serum “Ca” is increased and urinary “Ca”
is normal
(D) Both serum and urinary “Ca” are low
387.
The % of ‘K’ in Extracellular fluid is
about
(A)
1%
(B) 2 to 3%
(C)
10%
(D)
15%
388.
The Fe containing pigments is
(A) Haematoidin
(B) Bilirubin
(C) Hemasiderin
(D) Urobilinogen
389.
All of the following are true of
Wilson’s disease except
(A) Low total plasma Cu
(B) Elevated urinary copper
(C) Arthritis
(D) Aminoaciduria
390.
An increased serum ‘Iron’ and
decreased
‘Fe’
binding capacity are found in
(A) Fe-deficiency anaemia
(B) Sideroblastic anaemia
(C) Thalassaemia
(D) Anaemia of chromic disorders
391.
Iron therapy is ineffective in which
of the
following
conditions:
(A) Chronic blood loss
(B) Inadequate Fe intake
(C) Hypochromic anaemia of pregnancy
(D) Thalassaemia minor
392.
In hoemochromatosis, the liver is
infiltrat-
ed
with
(A) Copper
(B) Iron
(C) Manganese
(D) Chromium
393.
Which of the following is true?
Hypochromic anaemia is not due to iron deficiency except
(A) Serum ‘Fe’ is high
(B) Normal/low transferrin
(C) Stainable iron in bone marrow
(D) Iron therapy is affective
394.
Cytosolic superoxide dismutase
contains
(A) Zn only
(B) Cu only
(C) Zn and Cu
(D) Mn
395.
A rise in blood ‘Ca’ may indicate
(A) Paget’s disease
(B) Vitamin D deficiency
(C) Cushing’s disease
(D) Hypervitaminosis D
396.
The essential trace element which catalyzes
the formation of Hb in the body is
(A) Mn
(B) Se
(C) Mg
(D) Cu
397.
Zinc is a constituent of the enzyme:
(A) Succinate dehydrogenase
(B) Carbonic anhydrase
(C) Mitochondrial superoxide dismutase
(D) Aldolase
398.
The active transport of ‘Ca’ is
regulated by __________ which is synthesized in kidnyes.
(A) Cholecalciferol
(B) Ergosterol
(C)
25-OH cholecalciferol
(D) 1, 25-di OH-Cholecalciferol
399.
Ceruloplasmin shows the activity
(A) As ferroxidase
(B) As reductase
(C) As ligase
(D) As transferase
400.
The principal cation of extra cellular
fluid:
(A) K+
(B) Na+
(C) H+
(D) Ca2+
401.
What is the principal cation of
intracellular
fluid?
(A) K+
(B) Na+
(C) Ca2+
(D) Mg2+
402.
What is the normal level of K+
in the serum ?
(A)
137-148 mEq/L
(B)
120-160 mEq/L
(C) 3.9-5.0 mEq/L
(D)
0.3-0.59 mEq/L
403.
The general functions of minerals are
(A) The structural components of body tissues
(B) In the regulation of body fluids
(C) In acid-base balance
(D) All of these
404.
What are the functions of potassium?
(A) In muscle contraction
(B) Cell membrane function
(C) Enzyme action
(D) All of these
405.
The daily requirement of calcium is
(A)
200 mg
(B)
400 mg
(C) 800 mg
(D)
600 mg
406.
The normal serum inorganic phosphorous
level is
(A)
1.5-2.5 mg/100 ml
(B) 2.5-4.5 mg/100 ml
(C)
4.5-6.5 mg/100 ml
(D)
0.5-1.5 mg/100 ml
407.
When phosphorous level is lowered ?
(A) In hyper thyroidism
(B) Cirrosis of liver
(C) Leukemia
(D) Hypothyroidism
408.
Ferritin is
(A) Coenzyme
(B) One of the component of photophosphorylation
(C) It is the stored form of iron
(D) Non-protein moiety
409.
What is ceruloplasmin?
(A) Plasma protein
(B) Stored form of copper
(C) Both A and B
(D) None of these
410.
The following are the functions of copper:
(A) Constituent of cytochromes
(B) Catalase
(C) Tyrosinase
(D) All of these
411.
Zn is present as prosthetic group in
this
enzyme:
(A) Carbonic anhydrase
(B) Carboxy peptidase
(C) Lactate dehydrogenase
(D) All of these
412.
Fluorosis is caused due to
(A) Excessive intake of fluorine
(B) Low intake of fluorine
(C) Discoloration of the teeth due to low intake
(D) All of these
413.
What is the state of iron in
transferrin?
(A) Ferrous form
(B) Ferric form
(C) Both A and B
(D) None of these
414.
Haemoglobin formation needs both
(A) Iron and Zinc
(B) Iron and Calcium
(C) Iron and Copper
(D) Iron and Magnesium
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